Ontology highlight
ABSTRACT:
SUBMITTER: Mitra S
PROVIDER: S-EPMC6135741 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Mitra Soumitra S Sharma Poonam P Kaur Simran S Khursheed Mohammad Anwar MA Gupta Shivangi S Ahuja Riya R Kurup Akshai J AJ Chaudhary Mansi M Ramachandran Rajesh R
iScience 20180816
Histone deacetylases (Hdacs) play significant roles in cellular homeostasis and tissue differentiation. Hdacs are well characterized in various systems for their physiological and epigenetic relevance. However, their significance during retina regeneration remains unclear. Here we show that inhibition of Hdac1 causes a decline in regenerative ability, and injury-dependent regulation of hdacs is essential for regulating regeneration-associated genes like ascl1a, lin28a, and repressors like her4.1 ...[more]