Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
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ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC6135746 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Yu Jun J Hu Yinan Y Gao Yi Y Li Qinghai Q Zeng Zhilin Z Li Yong Y Chen Huilong H
Cell death discovery 20180912
Liver fibrosis, the common response associated with chronic liver diseases, ultimately leads to cirrhosis, a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) by transforming growth factor (TGF)-β1 is a key step in liver fibrosis. Here we report that Kindlin-2 expression is elevated in the livers of mice with experimental liver fibrosis and also in the livers of patients with liver fibrosis. TGF-β1 increases Kindlin-2 expression in cultured HSCs in a p38 and ERK ...[more]
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