Ontology highlight
ABSTRACT:
SUBMITTER: Smith KM
PROVIDER: S-EPMC6135763 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Smith Kate M KM Tsimbalyuk Sofiya S Edwards Megan R MR Cross Emily M EM Batra Jyoti J Soares da Costa Tatiana P TP Aragão David D Basler Christopher F CF Forwood Jade K JK
Nature communications 20180912 1
Seven human isoforms of importin α mediate nuclear import of cargo in a tissue- and isoform-specific manner. How nuclear import adaptors differentially interact with cargo harbouring the same nuclear localisation signal (NLS) remains poorly understood, as the NLS recognition region is highly conserved. Here, we provide a structural basis for the nuclear import specificity of W proteins in Hendra and Nipah viruses. We determine the structural interfaces of these cargo bound to importin α1 and α3, ...[more]