Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
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ABSTRACT:
SUBMITTER: Marenco S
PROVIDER: S-EPMC6135795 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Marenco Stefano S Meyer Christian C van der Veen Jan Willem JW Zhang Yan Y Kelly Ryan R Shen Jun J Weinberger Daniel R DR Dickinson Dwight D Berman Karen F KF
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20180703 11
GABAergic mechanisms have been shown to contribute to cognitive aging in animal models, but there is currently limited in vivo evidence to support this relationship in humans. It is also unclear whether aging is associated with changes in GABA levels measured with proton magnetic resonance spectroscopy (MRS). Spectral-editing MRS at 3 T was used to measure GABA in the dorsal anterior cingulate cortex (dACC) for a large sample of healthy volunteers (N = 229) aged 18-55. In a subset of 171 partici ...[more]
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