Ontology highlight
ABSTRACT:
SUBMITTER: Vachon-Presseau E
PROVIDER: S-EPMC6135815 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Vachon-Presseau Etienne E Berger Sara E SE Abdullah Taha B TB Huang Lejian L Cecchi Guillermo A GA Griffith James W JW Schnitzer Thomas J TJ Apkarian A Vania AV
Nature communications 20180912 1
The placebo response is universally observed in clinical trials of pain treatments, yet the individual characteristics rendering a patient a 'placebo responder' remain unclear. Here, in chronic back pain patients, we demonstrate using MRI and fMRI that the response to placebo 'analgesic' pills depends on brain structure and function. Subcortical limbic volume asymmetry, sensorimotor cortical thickness, and functional coupling of prefrontal regions, anterior cingulate, and periaqueductal gray wer ...[more]