Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC6135860 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhang Chong C Xu Ying Y Chowdhary Anirudh A Fox David D Gurney Mark E ME Zhang Han-Ting HT Auerbach Benjamin D BD Salvi Richard J RJ Yang Mingxin M Li Gaowen G O'Donnell James M JM
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20180814 11
Inhibitors of phosphodiesterase-4 (PDE4) have beneficial effects on memory in preclinical and clinical studies. Development of these drugs has stalled due to dose-limiting side effects of nausea and emesis. While use of subtype-selective inhibitors (i.e., for PDE4A, B, or D) could overcome this issue, conservation of the catalytic region, to which classical inhibitors bind, limits this approach. The present study examined the effects of BPN14770, an allosteric inhibitor of PDE4D, which binds to ...[more]