Ontology highlight
ABSTRACT:
SUBMITTER: Bordry N
PROVIDER: S-EPMC6136869 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bordry Natacha N Broggi Maria A S MAS de Jonge Kaat K Schaeuble Karin K Gannon Philippe O PO Foukas Periklis G PG Danenberg Esther E Romano Emanuela E Baumgaertner Petra P Fankhauser Manuel M Wald Noémie N Cagnon Laurène L Abed-Maillard Samia S Maby-El Hajjami Hélène H Murray Timothy T Ioannidou Kalliopi K Letovanec Igor I Yan Pu P Michielin Olivier O Matter Maurice M Swartz Melody A MA Speiser Daniel E DE
Oncoimmunology 20180531 8
Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) correlates with immune cell infiltration in primary tumors and lymph nodes (LNs) from patients with cutaneous melanoma. Using immunohistochemistry and quantitative image analysis, we found significant positive correlations between LVD and CD8< ...[more]