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High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.

ABSTRACT: In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

SUBMITTER: Wierz M 

PROVIDER: S-EPMC6136877 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.

Wierz Marina M   Janji Bassam B   Berchem Guy G   Moussay Etienne E   Paggetti Jerome J  

Oncoimmunology 20180524 8

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL. ...[more]

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