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Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.

ABSTRACT: Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize that phosphate deficiency altered the circadian cycle in peripheral tissues. Analysis of the expression of the central clock genes over a 24-36?hour period in multiple peripheral tissues including fracture callus, proximal tibia growth plate and cardiac tissues after 12 days on a low phosphate diet showed higher levels of gene expression in the hypophosphatemia groups (p?

SUBMITTER: Noguchi T

PROVIDER: S-EPMC6137060 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.

Noguchi Takashi T Hussein Amira I AI Horowitz Nina N Carroll Deven D Gower Adam C AC Demissie Serkalem S Gerstenfeld Louis C LC

Scientific reports 20180913 1

Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize that phosphate deficiency altered the circadian cycle in peripheral tissues. Analysis of the expression of the central clock genes over a 24-36 hour period in multiple peripheral tissues including fracture callus, proximal tibia growth plate and cardiac tissues after 12 days on a low phosphate diet showed ...[more]

PMID: 30213970

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