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A comprehensive manually-curated compendium of bovine transcription factors.

ABSTRACT: Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

SUBMITTER: de Souza MM

PROVIDER: S-EPMC6137171 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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A comprehensive manually-curated compendium of bovine transcription factors.

de Souza Marcela M MM Zerlotini Adhemar A Geistlinger Ludwig L Tizioto Polyana C PC Taylor Jeremy F JF Rocha Marina I P MIP Diniz Wellison J S WJS Coutinho Luiz L LL Regitano Luciana C A LCA

Scientific reports 20180913 1

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition ...[more]

PMID: 30213987

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