Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer.
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ABSTRACT:
SUBMITTER: Yasmin-Karim S
PROVIDER: S-EPMC6137176 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Radiation and Local Anti-CD40 Generate an Effective <i>in situ</i> Vaccine in Preclinical Models of Pancreatic Cancer.
Yasmin-Karim Sayeda S Bruck Patrick T PT Moreau Michele M Kunjachan Sijumon S Chen Gui Zhen GZ Kumar Rajiv R Grabow Stephanie S Dougan Stephanie K SK Ngwa Wilfred W
Frontiers in immunology 20180907
Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an <i>in situ</i> vaccine. In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a single dose of stereotactic body radiation therapy (SBRT) synergizes with intratumoral injection of agonistic anti-CD40, resulting in regression of non-treated contralateral tumors and formati ...[more]
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