Association of Temporal Changes in Gestational Age With Perinatal Mortality in the United States, 2007-2015.

ABSTRACT: Importance:Whether the changing gestational age distribution in the United States since 2005 has affected perinatal mortality remains unknown. Objective:To examine changes in gestational age distribution and gestational age-specific perinatal mortality. Design, Setting, and Participants:This retrospective cohort study examined trends in US perinatal mortality by linking live birth and infant death data among more than 35 million singleton births from January 1, 2007, through December 31, 2015. Exposures:Year of birth and changes in gestational age distribution. Main Outcomes and Measures:Changes in the proportion of births at gestational ages 20 to 27, 28 to 31, 32 to 33, 34 to 36, 37 to 38, 39 to 40, 41, and 42 to 44 weeks; changes in perinatal mortality (stillbirth at ?20 weeks, and neonatal deaths at <28 days) rates; and contribution of gestational age changes to perinatal mortality. Trends were estimated from log-linear regression models adjusted for confounders. Results:Among the 34?236?577 singleton live births during the study period, the proportion of births at all gestational ages declined, except at 39 to 40 weeks, which increased (54.5% in 2007 to 60.2% in 2015). Overall perinatal mortality declined from 9.0 to 8.6 per 1000 births (P?

SUBMITTER: Ananth CV 

PROVIDER: S-EPMC6137502 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature