Association of Early Inhaled Nitric Oxide With the Survival of Preterm Neonates With Pulmonary Hypoplasia.

ABSTRACT:

Importance

Pulmonary hypoplasia affects a very small percentage of preterm neonates, but its presence is associated with high rates of mortality.

Objective

To determine whether treatment with inhaled nitric oxide during the first week of life was associated with improved in-hospital survival in a cohort of extremely preterm neonates with pulmonary hypoplasia.

Design, setting, and participants

This cohort study used data from the Pediatrix Medical Group's Clinical Data Warehouse, a data set containing information from more than 350 neonatal intensive care units in 35 US states and Puerto Rico. Since inhaled nitric oxide was not randomly prescribed, we used 1-to-1 propensity score matching to reduce the imbalance of measured covariates between the 2 treatment groups. Th

SUBMITTER: Ellsworth KR 

PROVIDER: S-EPMC6137510 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature