Dataset Information

Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

ABSTRACT:

Rationale

Respiratory muscle weakness is common in critically ill patients; the role of targeted inspiratory muscle training (IMT) in intensive care unit rehabilitation strategies remains poorly defined.

Objectives

The primary objective of the present study was to describe the range and tolerability of published methods for IMT. The secondary objectives were to determine whether IMT improves respiratory muscle strength and clinical outcomes in critically ill patients.

Methods

We conducted a systematic review to identify randomized and nonrandomized studies of physical rehabilitation interventions intended to strengthen the respiratory muscles in critically ill adults. We searched the MEDLINE, Embase, HealthSTAR, CINAHL, and CENTRAL databases (inception to September Week 3, 2017) and conference proceedings (2012 to 2017). Data were independently extracted by two authors and collected on a standardized report form.

Results

A total of 28 studies (N?=?1,185 patients) were included. IMT was initiated during early mechanical ventilation (8 studies), after patients proved difficult to wean (14 studies), or after extubation (3 studies), and 3 other studies did not report exact timing. Threshold loading was the most common technique; 13 studies employed strength training regimens, 11 studies employed endurance training regimens, and 4 could not be classified. IMT was feasible, and there were few adverse events during IMT sessions (nine studies; median, 0%; interquartile range, 0-0%). In randomized trials (n?=?20), IMT improved maximal inspiratory pressure compared with control (15 trials; mean increase, 6 cm H₂O; 95% confidence interval [CI], 5-8 cm H₂O; pooled relative ratio of means, 1.19; 95% CI, 1.14-1.25) and maximal expiratory pressure (4 trials; mean increase, 9 cm H₂O; 95% CI, 5-14 cm H₂O). IMT was associated with a shorter duration of ventilation (nine trials; mean difference, 4.1 d; 95% CI, 0.8-7.4 d) and a shorter duration of weaning (eight trials; mean difference, 2.3 d; 95% CI, 0.7-4.0 d), but confidence in these pooled estimates was low owing to methodological limitations, including substantial statistical and methodological heterogeneity.

Conclusions

Most studies of IMT in critically ill patients have employed inspiratory threshold loading. IMT is feasible and well tolerated in critically ill patients and improves both inspiratory and expiratory muscle strength. The impact of IMT on clinical outcomes requires future confirmation.

SUBMITTER: Vorona S

PROVIDER: S-EPMC6137679 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Vorona Stefannie S Sabatini Umberto U Al-Maqbali Sulaiman S Bertoni Michele M Dres Martin M Bissett Bernie B Van Haren Frank F Martin A Daniel AD Urrea Cristian C Brace Debbie D Parotto Matteo M Herridge Margaret S MS Adhikari Neill K J NKJ Fan Eddy E Melo Luana T LT Reid W Darlene WD Brochard Laurent J LJ Ferguson Niall D ND Goligher Ewan C EC

Annals of the American Thoracic Society 20180601 6

<h4>Rationale</h4>Respiratory muscle weakness is common in critically ill patients; the role of targeted inspiratory muscle training (IMT) in intensive care unit rehabilitation strategies remains poorly defined.<h4>Objectives</h4>The primary objective of the present study was to describe the range and tolerability of published methods for IMT. The secondary objectives were to determine whether IMT improves respiratory muscle strength and clinical outcomes in critically ill patients.<h4>Methods</ ...[more]

PMID: 29584447

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Dataset Information

Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Rationale

Objectives

Methods

Results

Conclusions

Publications

Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Similar Datasets

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