Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC6138430 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zheng Yanyan Y Liu Qingxiang Q Wu Yaoxing Y Ma Ling L Zhang Zhenzhen Z Liu Tao T Jin Shouheng S She Yuanchu Y Li Yi-Ping YP Cui Jun J
The EMBO journal 20180731 18
Viral infection triggers host innate immune responses, which primarily include the activation of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) infection triggers NLRP3 inflammasome activation, which is further enhanced by viral non-structural protein NS1 to benefit its replication. NS1 recruits the host deubiquitinase USP8 to cleave K11-linked poly-ubiquitin chains from caspase-1 at Lys134, thus inhibiting the proteasomal degradation of caspase-1. Th ...[more]