Ontology highlight
ABSTRACT:
SUBMITTER: Martinho M
PROVIDER: S-EPMC6138654 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Martinho Marlène M Allegro Diane D Huvent Isabelle I Chabaud Charlotte C Etienne Emilien E Kovacic Hervé H Guigliarelli Bruno B Peyrot Vincent V Landrieu Isabelle I Belle Valérie V Barbier Pascale P
Scientific reports 20180914 1
Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of debate. We used Site Directed Spin Labeling combined with EPR spectroscopy to monitor Tau upon binding to either Taxol-stabilized MTs or to αβ-tubulin when Tau is directly used as an in ...[more]