Ontology highlight
ABSTRACT:
SUBMITTER: Neubert E
PROVIDER: S-EPMC6138659 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Neubert Elsa E Meyer Daniel D Rocca Francesco F Günay Gökhan G Kwaczala-Tessmann Anja A Grandke Julia J Senger-Sander Susanne S Geisler Claudia C Egner Alexander A Schön Michael P MP Erpenbeck Luise L Kruss Sebastian S
Nature communications 20180914 1
Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps (NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been documented for other cells and organisms, thus highlighting the evolutionary conservation of this process. Moreover, dysregulated NETosis has been implicated in many diseases, including cancer and inflammatory disorders. During NETosis, neutrophils undergo dynamic and dramatic alterations of their cellular as well as sub-ce ...[more]