Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen D
PROVIDER: S-EPMC6138672 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nguyen Duy D Stutz Regine R Schorr Stefan S Lang Sven S Pfeffer Stefan S Freeze Hudson H HH Förster Friedrich F Helms Volkhard V Dudek Johanna J Zimmermann Richard R
Nature communications 20180914 1
In mammalian cells, one-third of all polypeptides are transported into or across the ER membrane via the Sec61 channel. While the Sec61 complex facilitates translocation of all polypeptides with amino-terminal signal peptides (SP) or transmembrane helices, the Sec61-auxiliary translocon-associated protein (TRAP) complex supports translocation of only a subset of precursors. To characterize determinants of TRAP substrate specificity, we here systematically identify TRAP-dependent precursors by an ...[more]