Ontology highlight
ABSTRACT:
SUBMITTER: Luijk R
PROVIDER: S-EPMC6138682 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180914 1
X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a replication sample of 3351 females, we show that genetic variation at three autosomal loci is associated with female-specific ch ...[more]