The correlation between microRNA-221/222 cluster overexpression and malignancy: an updated meta-analysis including 2693 patients.

ABSTRACT:

Background

Although miR-221/222 cluster plays an important role in many human malignancies, the correlation between miR-221/222 cluster overexpression and tumor prognosis remains controversial. Therefore, an updated meta-analysis was conducted to clarify its prognostic value in malignancy.

Methods

We conducted a search of literature in English electronic databases of PubMed, Embase, and Cochrane Library, and Chinese electronic databases of China Biology Medicine disc and China National Knowledge Infrastructure to obtain appropriate studies. Besides, we extracted hazard ratios (HRs) and 95% CIs to evaluate the strength of the correlations. In addition, the results of different subgroups analyses and publication bias test were also shown in this article.

Results

32 publ

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6138959 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature