Dataset Information

Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

ABSTRACT:

Background

Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and 46 days of age has been extensively studied; however, the reproducibility and generalizability of these methods are controversial in a general clinical setting. Therefore, we investigated the prognostic performance of conventional H-MRS during first 96 postnatal hours in hypothermia-treated asphyxiated neonates.

Methods

Fifty-one consecutive hypothermia-treated HIE neonates were examined by H-MRS at three echo-times (TE?=?35, 144, 288 ms) between 6 and 96 h of age, depending on clinical stability. Patients were divided into favorable (n?=?35) and unfavorable (n?=?16) outcome groups based on psychomotor and mental developmental index (PDI and MDI, Bayley Scales of Infant Development II) scores (? 70 versus ResultsThree metabolite ratios showed significant difference between outcome groups after correction for multiple testing (p?ConclusionsOur findings suggest that during first 96 h of age even conventional H-MRS could be a useful prognostic tool in predicting the outcome of asphyxiated neonates; mIns/NAA was found to be the best and age-independent predictor.

SUBMITTER: Barta H

PROVIDER: S-EPMC6139158 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

Barta Hajnalka H Jermendy Agnes A Kolossvary Marton M Kozak Lajos R LR Lakatos Andrea A Meder Unoke U Szabo Miklos M Rudas Gabor G

BMC pediatrics 20180915 1

<h4>Background</h4>Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and 46 days of age has been extensively studied; however, the reproducibility and generalizability of these methods are controversial in a general clinical setting. Therefore, we investigated the prognostic performance of conventional H-MRS dur ...[more]

PMID: 30219051

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Dataset Information

Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

Background

Methods

Publications

Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

Similar Datasets

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