Differential expression of NF-κB heterodimer RelA/p50 in human urothelial carcinoma.

ABSTRACT:

Background

Urothelial carcinoma (UC) is the fifth most common malignancy that accounts for 5% of all cancers. Diagnostic markers that predict UC progressions are inadequate. NF-κB contributes towards disease progression upon constitutive activation in many solid tumors. The nuclear localization of NF-κB indicates increased transcriptional activity while cytoplasmic localization indicates the inactive protein repository that can be utilized readily by a malignant cell. This study delineates the nuclear and cytoplasmic differential expression of NF-κB heterodimers in UC progression.

Methods

The involvement of the NF-κB proteins in UC was analyzed in silico using cytoscape. The expression of NF-κB heterodimers was analyzed by immunohistochemistry.

Results

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SUBMITTER: Durairajan S 

PROVIDER: S-EPMC6139250 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature