Dataset Information

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children.

ABSTRACT: Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8-14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82?mg/dl and 11.0 ?IU/ml in boys and 77.3?mg/dl and 12.3 ?IU/ml in girls (P < 0.05). Subjects with obesity at Tanner stages II-V showed increased FG levels (P < 0.05). In boys with obesity, there was a decrease in HOMA-IR in Tanner stage IV and differences in age between boys with normal weight and those with obesity in Tanner V, being older the boys with obesity. Obesity in children and adolescents was associated with higher HOMA-IR values. In boys with obesity, IR increased at the end of pubertal maturation, with a delay in puberty. These findings should be considered on the establishment of IR cutoff values for pubertal population in Mexico and in the establishment of strategies to prevent the health problems related to obesity.

SUBMITTER: Cardenas-Vargas E

PROVIDER: S-EPMC6140127 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children.

Cardenas-Vargas Edith E Nava Jairo A JA Garza-Veloz Idalia I Torres-Castañeda Mayra C MC Galván-Tejada Carlos E CE Cid-Baez Miguel A MA Castañeda-Arteaga Rosa E RE Ortiz-Castro Yolanda Y Trejo-Ortiz Perla M PM Araujo-Espino Roxana R Mollinedo-Montaño Fabiana E FE Muñoz-Torres Jose R JR Martinez-Fierro Margarita L ML

International journal of endocrinology 20180903

Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8-14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82 mg/dl and 11.0 <i>μ</i>IU/ml in boys and 77.3 mg/dl and 12.3 ...[more]

PMID: 30254673

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Project description:BackgroundObesity is characterized by adipose tissue dysregulation and predisposes individuals to insulin resistance and type 2 diabetes. At the molecular level, adipocyte dysfunction has been linked to obesity-triggered oxidative stress and protein carbonylation, considering protein carbonylation as a link between oxidative stress and metabolic dysfunction. The identification of specific carbonylated proteins in adipose tissue could provide novel biomarkers of oxidative damage related to metabolic status (i.e prediabetes). Thus, we aimed at characterizing the subcutaneous and omental human adipose tissue carbonylome in obesity-associated insulin resistance.Methods2D-PAGE was used to identify carbonylated proteins, and clinical correlations studies and molecular biology approaches including intracellular trafficking, reactive oxygen species assay, and iron content were performed using in vitro models of insulin resistance.ResultsThe carbonylome of human adipose tissue included common (serotransferrin, vimentin, actin, and annexin A2) and depot-specific (carbonic anhydrase and α-crystallin B in the subcutaneous depot; and α-1-antitrypsin and tubulin in the omental depot) differences that point out the complexity of oxidative stress at the metabolic level, highlighting changes in carbonylated transferrin expression. Posterior studies using in vitro prediabetic model evidence alteration in transferrin receptor translocation, linked to the prediabetic environment. Finally, ligand-receptor molecular docking studies showed a reduced affinity for carbonylated transferrin binding to its receptor compared to wild-type transferrin, emphasizing the role of transferrin carbonylation in the link between oxidative stress and metabolic dysfunction.ConclusionsThe adipose tissue carbonylome contributes to understanding the molecular mechanism driving adipocyte dysfunction and identifies possible adipose tissue carbonylated targets in obesity-associated insulin resistance.

Dataset Information

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children.

Publications

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children.

Similar Datasets

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