Ontology highlight
ABSTRACT:
SUBMITTER: Varlakhanova NV
PROVIDER: S-EPMC6140320 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Varlakhanova Natalia V NV Tornabene Bryan A BA Ford Marijn G J MGJ
Journal of cell science 20180907 17
The highly conserved TORC1 complex controls cell growth in response to nutrients, especially amino acids. The EGO complex activates TORC1 in response to glutamine and leucine. Here, we demonstrate that the I-BAR domain-containing protein Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex. Ivy1 is a negative regulator of Gtr-induced TORC1 activation, and is contained within puncta associated with the vacuolar membrane in cells grown in nutrient-ri ...[more]