Ontology highlight
ABSTRACT:
SUBMITTER: Maezawa S
PROVIDER: S-EPMC6140322 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Maezawa So S Hasegawa Kazuteru K Alavattam Kris G KG Funakoshi Mayuka M Sato Taiga T Barski Artem A Namekawa Satoshi H SH
Journal of cell science 20180903 17
Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here, we identify SCML2, a germline-specific Polycomb protein, as a critical regulator of heterochromatin organization in spermatogenesis. We show that SCML2 accumulates on pericentromeric heterochromatin (PCH) in male germ cells, where it suppresses PRC1-mediated monoubiquitylation of histone H2A at Lysine 119 (H2AK119ub) and ...[more]