Ontology highlight
ABSTRACT:
SUBMITTER: Handoko L
PROVIDER: S-EPMC6140815 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Handoko Lusy L Kaczkowski Bogumil B Hon Chung-Chau CC Lizio Marina M Wakamori Masatoshi M Matsuda Takayoshi T Ito Takuhiro T Jeyamohan Prashanti P Sato Yuko Y Sakamoto Kensaku K Yokoyama Shigeyuki S Kimura Hiroshi H Minoda Aki A Umehara Takashi T
Epigenetics 20180806 4
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET protein association to histone H4-hyperacetylated chromatin is not understood at the genome-wide level. Here, we report transcription start site (TSS)-resolution integrative analyses of ChIP-seq and transcriptome profiles in human non-small cell lu ...[more]