Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD: Relation to Disease Progression.
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ABSTRACT:
SUBMITTER: Moreira Soares Oliveira B
PROVIDER: S-EPMC6140833 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Exploratory Profiling of Urine MicroRNAs in the <i>dy<sup>2J</sup>/dy<sup>2J</sup></i> Mouse Model of LAMA2-CMD: Relation to Disease Progression.
Moreira Soares Oliveira Bernardo B Gawlik Kinga I KI Durbeej Madeleine M Holmberg Johan J
PLoS currents 20180827
Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the <i>dy<sup>2J</sup></i> /<i>dy<sup>2J</sup></i> mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, in ...[more]
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