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Protein X-ray crystallography of the 14-3-3?/SOS1 complex.

ABSTRACT: Activation of Ras-MAPK signaling regulates essential cellular functions; its aberration leads to irregular cell proliferation and differentiation (i.e. pancreatic cancer). Previously, it was revealed that the formation of the complex of the 14-3-3 protein and the Son of sevenless homolog 1 (SOS1) - one of the main actors of the Ras-MAPK cascade -, would represent a key-process to downstream the deviant Ra-MAPK signaling. In this data article we attempt to shed some light on the 3D structure, providing useful details about the crystallization process of the 14-3-3? dimer in complex with the 13-mer SOS1pS1161. The crystal structure is deposited at the Protein Data Bank with identifier 6F08. This Data in Brief article refers to "Structural characterization of 14-3-3? in complex with the human Son of sevenless homolog 1 (SOS1) (2018)."

SUBMITTER: Ballone A

PROVIDER: S-EPMC6141376 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex.

Ballone Alice A Centorrino Federica F Wolter Madita M Ottmann Christian C

Data in brief 20180628

Activation of Ras-MAPK signaling regulates essential cellular functions; its aberration leads to irregular cell proliferation and differentiation (i.e. pancreatic cancer). Previously, it was revealed that the formation of the complex of the 14-3-3 protein and the Son of sevenless homolog 1 (SOS1) - one of the main actors of the Ras-MAPK cascade -, would represent a key-process to downstream the deviant Ra-MAPK signaling. In this data article we attempt to shed some light on the 3D structure, pro ...[more]

PMID: 30229043

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