Ontology highlight
ABSTRACT:
SUBMITTER: Ingles J
PROVIDER: S-EPMC6141493 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ingles Judith J Simpson Arren A Kyathanahalli Chandrashekara C Anamthathmakula Prashanth P Hassan Sonia S Jeyasuria Pancharatnam P Condon Jennifer C JC
Cell death & disease 20180917 10
The prevention of apoptotic caspase 3 activation through biological preconditioning, mediated through the modulation of the unfolded protein response has been demonstrated to ameliorate multiple pathophysiologies. The maintenance of non-apoptotic caspase 3 activity by the unfolded protein response within the pregnant uterus has previously been proven to be critical in inhibiting uterine myocyte contractility during pregnancy. Here we report that the pregnant uterus utilizes an unfolded protein r ...[more]