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Assembly of Plasmonic and Magnetic Nanoparticles with Fluorescent Silica Shell Layer for Tri-functional SERS-Magnetic-Fluorescence Probes and Its Bioapplications.

ABSTRACT: In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic Fe3O4 nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF-SERS particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS and fluorescence signals could be detected from the NP-containing cells, and CD44 antibody-conjugated MF-SERS particles selectively targeted MDA-MB-231 cells. Based on these properties, MF-SERS particles proved to be a useful nanoprobe for multiplex detection and separation of cancer cells.

SUBMITTER: Kim HM 

PROVIDER: S-EPMC6141549 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Assembly of Plasmonic and Magnetic Nanoparticles with Fluorescent Silica Shell Layer for Tri-functional SERS-Magnetic-Fluorescence Probes and Its Bioapplications.

Kim Hyung-Mo HM   Kim Dong-Min DM   Jeong Cheolhwan C   Park So Yeon SY   Cha Myeong Geun MG   Ha Yuna Y   Jang Dahye D   Kyeong San S   Pham Xuan-Hung XH   Hahm Eunil E   Lee Sang Hun SH   Jeong Dae Hong DH   Lee Yoon-Sik YS   Kim Dong-Eun DE   Jun Bong-Hyun BH  

Scientific reports 20180917 1

In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF-SERS particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS  ...[more]

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