Ontology highlight
ABSTRACT:
SUBMITTER: Rhodes SJ
PROVIDER: S-EPMC6141590 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rhodes Sophie J SJ Guedj Jeremie J Fletcher Helen A HA Lindenstrøm Thomas T Scriba Thomas J TJ Evans Thomas G TG Knight Gwenan M GM White Richard G RG
NPJ vaccines 20180917
Unlike drug dose optimisation, mathematical modelling has not been applied to vaccine dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical modelling framework to translate multi-dose TB vaccine immune responses from mice, to predict most immunogenic dose in humans. Data were previously collected on IFN-γ secreting CD4+ T cells over time for novel TB vaccines H56 and H1 adjuvanted with IC31 in mice (1 dose groups (0.1-1.5 and 15 μg H56 + IC31), 45 mice) and humans (1 dose ...[more]