Anterior-posterior gradient of plasticity in primate prefrontal cortex.

ABSTRACT: The functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neur

SUBMITTER: Riley MR 

PROVIDER: S-EPMC6141600 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature