Ontology highlight
ABSTRACT:
SUBMITTER: Megrelis L
PROVIDER: S-EPMC6141708 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in immunology 20180911
We previously identified Fam65b as an atypical inhibitor of the small G protein RhoA. Using a conditional model of a Fam65b-deficient mouse, we first show that Fam65b restricts spontaneous RhoA activation in resting T lymphocytes and regulates intranodal T cell migration <i>in vivo</i>. We next aimed at understanding, at the molecular level, how the brake that Fam65b exerts on RhoA can be relieved upon signaling to allow RhoA activation. Here, we show that chemokine stimulation phosphorylates Fa ...[more]