Ontology highlight
ABSTRACT:
SUBMITTER: Sato Y
PROVIDER: S-EPMC6141740 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Sato Yoshiaki Y Shinjyo Noriko N Sato Machiko M Nilsson Marie K L MKL Osato Kazuhiro K Zhu Changlian C Pekna Marcela M Kuhn Hans G HG Blomgren Klas K
Frontiers in neurology 20180911
The pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus of the hippocampus is reduced by ionizing radiation. This explains, at least partly, the learning deficits observed in patients after radiotherapy, particularly in pediatric cases. An 8 Gy single irradiation dose was delivered to the whole brains of postnatal day 9 (P9) C57BL/6 mice, and BrdU-labeled, syngeneic NSPCs (1.0 × 10<sup>5</sup> cells/injection) were grafted into each hippocampus on P21. Three months later, behav ...[more]