Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC6142180 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20180326 19
Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of such channels remains challenging owing to the difficulty in probing subtle gating-associated structural changes. Herein, we show that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when its charge is neutralized by Mg<sup>2+</sup> ; wherea ...[more]