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ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus.

ABSTRACT: BACKGROUND:Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced cardiovascular disease, such approaches are limited for individuals with high genetic T2D risk. In this study we investigated possible associations of ACE2 polymorphisms and cardiovascular risks in Uygur patients with T2D. METHODS:275 Uygur T2D patients and 272 non-diabetic Uygur individuals were enrolled as study participants. 14 ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. RESULTS:ACE2 SNP rs1978124, rs2048683, rs2074192, rs233575, rs4240157, rs4646156, rs4646188 and rs879922 were associated with T2D (all P?

SUBMITTER: Liu C

PROVIDER: S-EPMC6142339 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus.

Liu Cheng C Li Yanfang Y Guan Tianwang T Lai Yanxian Y Shen Yan Y Zeyaweiding Abudurexiti A Zhao Haiyan H Li Fang F Maimaiti Tutiguli T

Cardiovascular diabetology 20180918 1

<h4>Background</h4>Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced cardiovascular disease, such approaches are limited for individuals with high genetic T2D risk. In this study we investigated possible associations of ACE2 polymorphisms and cardiovascular risks in Uygur patients with T2D.<h4>Me ...[more]

PMID: 30227878

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