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Correlation between CTLA-4 and CD40 gene polymorphisms and their interaction in graves' disease in a Chinese Han population.

ABSTRACT: BACKGROUND:Single-nucleotide polymorphism (SNP) haplotype and SNP-SNP interactions of CTLA-4 and CD40 genes, with susceptibility to Graves' disease (GD), were explored in a Chinese Han population. METHODS:SNP were genotyped by high resolution melting (HRM). Use the method of Pearson ?2 test and Logistic regression for the association between single SNP and Graves' disease. Using the method of ?2 test and Multifactor Dimensionality Reduction (MDR) to analysis the haplotype frequency distribution, the interaction of SNPs respectively. RESULTS:Genotypic and allelic frequencies of SNP rs231775, rs3087243 and rs1883832 were statistically different between controls and GD (p < 0.05). Mutant allelic frequency of G rs231775 was higher, and A and T allelic frequencies of rs3087243 and rs1883832 were lower in GD than in controls (P?

SUBMITTER: Chen X

PROVIDER: S-EPMC6142355 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Correlation between CTLA-4 and CD40 gene polymorphisms and their interaction in graves' disease in a Chinese Han population.

Chen Xiaoming X Hu Zhuoqing Z Liu Meilian M Li Huaqian H Liang Chanbo C Li Wei W Bao Liwen L Chen Manyang M Wu Ge G

BMC medical genetics 20180917 1

<h4>Background</h4>Single-nucleotide polymorphism (SNP) haplotype and SNP-SNP interactions of CTLA-4 and CD40 genes, with susceptibility to Graves' disease (GD), were explored in a Chinese Han population.<h4>Methods</h4>SNP were genotyped by high resolution melting (HRM). Use the method of Pearson χ2 test and Logistic regression for the association between single SNP and Graves' disease. Using the method of χ2 test and Multifactor Dimensionality Reduction (MDR) to analysis the haplotype frequenc ...[more]

PMID: 30223781

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Compelling Evidence Linking CD40 Gene With Graves' Disease in the Chinese Han Population.

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