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Treatment options for patients with myelodysplastic syndromes after hypomethylating agent failure.

ABSTRACT: The treatment of patients with myelodysplastic syndromes (MDSs) has hinged primarily on supportive care (ie, blood transfusions, colony stimulating agents, iron chelation, etc.) and the US Food and Drug Administration-approved agents, including 5-azacytidine, deoxyazacytidine, and lenalidomide. For patients no longer benefitting from these agents, there is a paucity of effective therapies. The challenges at this time include our limited understanding of the mechanisms of resistance to these therapies and the variables employed to select next best therapies for patients based on: (1) their performance status and medical comorbidities; (2) the molecular feature(s) of their MDS; (3) the prior treatments they have received; and (4) the long-term goal(s)/possibilities for their future treatment (ie, transplant vs no transplant).

SUBMITTER: Carraway HE

PROVIDER: S-EPMC6142467 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Treatment options for patients with myelodysplastic syndromes after hypomethylating agent failure.

Carraway Hetty E HE

Hematology. American Society of Hematology. Education Program 20161201 1

The treatment of patients with myelodysplastic syndromes (MDSs) has hinged primarily on supportive care (ie, blood transfusions, colony stimulating agents, iron chelation, etc.) and the US Food and Drug Administration-approved agents, including 5-azacytidine, deoxyazacytidine, and lenalidomide. For patients no longer benefitting from these agents, there is a paucity of effective therapies. The challenges at this time include our limited understanding of the mechanisms of resistance to these ther ...[more]

PMID: 27913518

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Beyond hypomethylating agents failure in patients with myelodysplastic syndromes.

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