Evolving treatment paradigms in sickle cell disease.
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ABSTRACT:
SUBMITTER: Jagadeeswaran R
PROVIDER: S-EPMC6142561 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Evolving treatment paradigms in sickle cell disease.
Jagadeeswaran Ramasamy R Rivers Angela A
Hematology. American Society of Hematology. Education Program 20171201 1
Sickle cell disease (SCD) is an inheritable hemoglobinopathy characterized by polymerization of hemoglobin S in red blood cells resulting in chronic hemolytic anemia, vaso-occlusive painful crisis, and multiorgan damage. In SCD, an increased reactive oxygen species (ROS) generation occurs both inside the red blood cells and inside the vascular lumen, which augment hemolysis and cellular adhesion. This review discusses the evolving body of literature on the role of ROS in the pathophysiology of S ...[more]
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