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Catalyst-free synthesis of 4-acyl-NH-1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide.

ABSTRACT: The synthesis of 4-acyl-NH-1,2,3-triazoles has been accomplished with high efficiency through the cycloaddition reactions between N,N-dimethylenaminones and tosyl azide. This method is featured with extraordinary sustainability by employing water as the sole medium, free of any catalyst or additive, authentically mild conditions (40 °C stirring) as well as practical scalability.

SUBMITTER: Yang L

PROVIDER: S-EPMC6142726 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Catalyst-free synthesis of 4-acyl-NH-1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide.

Yang Lu L Wu Yuwei Y Yang Yiming Y Wen Chengping C Wan Jie-Ping JP

Beilstein journal of organic chemistry 20180907

The synthesis of 4-acyl-NH-1,2,3-triazoles has been accomplished with high efficiency through the cycloaddition reactions between N,N-dimethylenaminones and tosyl azide. This method is featured with extraordinary sustainability by employing water as the sole medium, free of any catalyst or additive, authentically mild conditions (40 °C stirring) as well as practical scalability. ...[more]

PMID: 30254699

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