Ontology highlight
ABSTRACT:
SUBMITTER: Miller ML
PROVIDER: S-EPMC6142813 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Miller Michelle L ML McIntosh Christine M CM Williams Jason B JB Wang Ying Y Hollinger Maile K MK Isaad Noel J NJ Moon James J JJ Gajewski Thomas F TF Chong Anita S AS Alegre Maria-Luisa ML
Cell reports 20180801 8
Mechanisms implicated in robust transplantation tolerance at the cellular level can be broadly categorized into those that inhibit alloreactive T cells intrinsically (clonal deletion and dysfunction) or extrinsically through regulation. Here, we investigated whether additional population-level mechanisms control T cells by examining whether therapeutically induced peripheral transplantation tolerance could influence T cell populations' avidity for alloantigens. Whereas T cells with high avidity ...[more]