Ontology highlight
ABSTRACT:
SUBMITTER: Furotani K
PROVIDER: S-EPMC6143267 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Furotani Koto K Kamimura Keisuke K Yajima Takaaki T Nakayama Minoru M Enomoto Rena R Tamura Takuya T Okazawa Hitoshi H Sone Masaki M
PloS one 20180918 9
APP (amyloid precursor protein), the causative molecule of Alzheimer's disease, is synthesized in neuronal cell bodies and subsequently transported to synapses. We previously showed that the yata gene is required for the synaptic transport of the APP orthologue in Drosophila melanogaster. In this study, we examined the effect of a reduction in yata expression in the Drosophila Alzheimer's disease model, in which expression of human mutant APP was induced. The synaptic localization of APP and oth ...[more]