Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins.
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ABSTRACT:
SUBMITTER: Wexler AG
PROVIDER: S-EPMC6143338 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Human gut <i>Bacteroides</i> capture vitamin B<sub>12</sub> via cell surface-exposed lipoproteins.
Wexler Aaron G AG Schofield Whitman B WB Degnan Patrick H PH Folta-Stogniew Ewa E Barry Natasha A NA Goodman Andrew L AL
eLife 20180918
Human gut <i>Bacteroides</i> use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other or the host for these critical resources. Unlike in <i>Escherichia coli</i>, transport loci for vitamin B<sub>12</sub> (cobalamin) and other corrinoids in human gut <i>Bacteroides</i> are replete with conserved genes encoding proteins who ...[more]
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