Ontology highlight
ABSTRACT:
SUBMITTER: Karpel-Massler G
PROVIDER: S-EPMC6143391 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Karpel-Massler Georg G Ishida Chiaki Tsuge CT Zhang Yiru Y Halatsch Marc-Eric ME Westhoff M-Andrew MA Siegelin Markus D MD
Expert opinion on drug discovery 20170720 10
<h4>Introduction</h4>Novel approaches to treat malignant brain tumors are necessary since these neoplasms still display an unfavorable prognosis. Areas covered: In this review, the authors summarize and analyze recent preclinical data that suggest that targeting intrinsic apoptosis may be a suitable strategy for the treatment of malignant gliomas. They focus on the anti-apoptotic Bcl-2 family members of proteins and the recent drug developments in that field with a special focus on BH3-mimetics. ...[more]