Ontology highlight
ABSTRACT:
SUBMITTER: Bridgford JL
PROVIDER: S-EPMC6143634 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Bridgford Jessica L JL Xie Stanley C SC Cobbold Simon A SA Pasaje Charisse Flerida A CFA Herrmann Susann S Yang Tuo T Gillett David L DL Dick Lawrence R LR Ralph Stuart A SA Dogovski Con C Spillman Natalie J NJ Tilley Leann L
Nature communications 20180918 1
Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechanism of action of ARTs. Here we demonstrate that dihydroartemisinin (DHA), the clinically relevant ART, kills parasites via a two-pronged mechanism, causing protein damage, and compr ...[more]