3D multiscale imaging of human vocal folds using synchrotron X-ray microtomography in phase retrieval mode.

ABSTRACT: Human vocal folds possess outstanding abilities to endure large, reversible deformations and to vibrate up to more than thousand cycles per second. This unique performance mainly results from their complex specific 3D and multiscale structure, which is very difficult to investigate experimentally and still presents challenges using either confocal microscopy, MRI or X-ray microtomography in absorption mode. To circumvent these difficulties, we used high-resolution synchrotron X-ray microtomography with phase retrieval and report the first ex vivo 3D images of human vocal-fold tissues at multiple scales. Various relevant descriptors of structure were extracted from the images: geometry of vocal folds at rest or in a stretched phonatory-like position, shape and size of their layered fibrous

SUBMITTER: Bailly L 

PROVIDER: S-EPMC6143640 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature