Ontology highlight
ABSTRACT:
SUBMITTER: Lighaam LC
PROVIDER: S-EPMC6143818 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lighaam Laura C LC Unger Peter-Paul A PA Vredevoogd David W DW Verhoeven Dorit D Vermeulen Ellen E Turksma Annelies W AW Ten Brinke Anja A Rispens Theo T van Ham S Marieke SM
Frontiers in immunology 20180905
Regulatory B cells (Breg) have been described as a specific immunological subsets in several mouse models. Identification of a human counterpart has remained troublesome, because unique plasma membrane markers or a defining transcription factor have not been identified. Consequently, human Bregs are still primarily defined by production of IL-10. In this study, we sought to elucidate if <i>in vitro-</i>induced human IL-10 producing B cells are a dedicated immunological subset. Using deep immune ...[more]