Dataset Information

Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA.

ABSTRACT:

Objectives

To examine the association between neighbourhood deprivation and lung cancer risk.

Design

Nested case-control study.

Setting

Southern Community Cohort Study of persons residing in 12 states in the southeastern USA.

Participants

1334 cases of lung cancer and 5315 controls.

Primary outcome measure

Risk of lung cancer.

Results

After adjustment for smoking status and other confounders, and additional adjustment for individual-level measures of socioeconomic status (SES), there was no monotonic increase in risk with worsening deprivation score overall or within sex and race groups. There was an increase among current and shorter term former smokers (p=0.04) but not among never and longer term former smokers. There was evidence of statistically significant interaction by sex among whites, but not blacks, in which the effect of worsening deprivation on lung cancer existed in males but not in females.

Conclusions

Area-level measures of SES were associated with lung cancer risk in current and shorter term former smokers only in this population.

SUBMITTER: Sanderson M

PROVIDER: S-EPMC6144393 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA.

Sanderson Maureen M Aldrich Melinda C MC Levine Robert S RS Kilbourne Barbara B Cai Qiuyin Q Blot William J WJ

BMJ open 20180910 9

<h4>Objectives</h4>To examine the association between neighbourhood deprivation and lung cancer risk.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>Southern Community Cohort Study of persons residing in 12 states in the southeastern USA.<h4>Participants</h4>1334 cases of lung cancer and 5315 controls.<h4>Primary outcome measure</h4>Risk of lung cancer.<h4>Results</h4>After adjustment for smoking status and other confounders, and additional adjustment for individual-level measures of so ...[more]

PMID: 30206077

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Project description:BackgroundA role for vitamin D in cancer risk reduction has been hypothesized, but few data exist for lung cancer. We investigated the relationship between vitamin D status, using circulating 25-hydroxyvitamin D [25(OH)D], and lung cancer risk in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers.MethodsLung cancer cases (n = 500) were randomly selected based on month of blood collection, and 500 controls were matched to them based on age and blood collection date. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate-adjusted conditional logistic regression. To account for seasonal variation in 25(OH)D concentrations, season-specific and season-standardized quintiles of 25(OH)D were examined, and models were also stratified on season of blood collection (darker season = November-April and sunnier season = May-October). Pre-determined, clinically-defined cutpoints for 25(OH)D and 25(OH)D as a continuous measure were also examined.ResultsOverall, 25(OH)D was not associated with lung cancer. Risks were 1.08 (95% CI 0.67-1.75) and 0.83 (95% CI 0.53-1.31) in the highest vs. lowest season-specific and season-standardized quintiles of 25(OH)D, respectively, and 0.91 (95% CI 0.48-1.72) for the ≥75 vs. <25 nmol/L clinical categories. Inverse associations were, however, suggested for subjects with blood collections from November-April, with ORs of 0.77 (95% CI 0.41-1.45, p-trend = 0.05) and 0.65 (95% CI 0.37-1.14, p-trend = 0.07) in the highest vs. lowest season-specific and season-standardized quintiles of 25(OH)D, respectively, and 0.61 (95% CI 0.24-1.52, p-trend = 0.01) for ≥75 vs. <25 nmol/L. We also found 11% lower risk for a 10 nmol/L increase in 25(OH)D in the darker season based on the continuous measure (OR = 0.89, 95% CI 0.81-0.98, p = 0.02).ConclusionIn this prospective study of male smokers, circulating 25(OH)D was not associated with lung cancer risk overall, although inverse associations were suggested among those whose blood was drawn during darker months.

Dataset Information

Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA.

Objectives

Design

Setting

Participants

Primary outcome measure

Results

Conclusions

Publications

Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA.

Similar Datasets

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