Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto S
PROVIDER: S-EPMC6144811 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20180901 16
Programmed -1 ribosomal frameshifting (-1PRF) is a recoding mechanism to make alternative proteins from a single mRNA transcript. -1PRF is stimulated by cis-acting signals in mRNA, a seven-nucleotide slippery sequence and a downstream secondary structure element, which is often a pseudoknot. In this study we engineered the frameshifting pseudoknot from the mouse mammary tumor virus to respond to a rationally designed small molecule naphthyridine carbamate tetramer (NCTn). We demonstrate that NCT ...[more]