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Genome characterization of bile-isolated Shewanella algae ACCC.

ABSTRACT: Background:Shewanella algae has been recognized as an emerging human pathogen. However, not much is known about the mechanism of its pathogenesis and its adaptation to a special niche such as the hepatobiliary tract. Results:In this study, we isolated the S. algae ACCC strain from human bile and performed whole genome sequencing. S. algae ACCC consists of a circular 4,743,354-bp chromosome with a GC content of 53.08%, within 4080 protein coding sequences. The genome of strain ACCC contains a number of candidate genes which have been reported to be associated with bile adaption, including htpB, exbBD, wecA, galU, adeFGH and phoPQ regulon. Conclusions:Our results highlight the association of S. algae with a rare disease profile. Further studies are needed to shed light on the evolution of pathogenesis and the niche adaptation of S. algae.

SUBMITTER: Tseng SY

PROVIDER: S-EPMC6145196 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Genome characterization of bile-isolated <i>Shewanella algae</i> ACCC.

Tseng Shu-Ying SY Tung Kwong-Chung KC Cheng Jan-Fang JF Lee Yi-Hsuan YH Wu Zong-Yen ZY Hong Yu-Kai YK Chen Shi-Yu SY Huang Yao-Ting YT Liu Po-Yu PY

Gut pathogens 20180918

<h4>Background</h4><i>Shewanella algae</i> has been recognized as an emerging human pathogen. However, not much is known about the mechanism of its pathogenesis and its adaptation to a special niche such as the hepatobiliary tract.<h4>Results</h4>In this study, we isolated the <i>S. algae</i> ACCC strain from human bile and performed whole genome sequencing. <i>S. algae</i> ACCC consists of a circular 4,743,354-bp chromosome with a GC content of 53.08%, within 4080 protein coding sequences. The ...[more]

PMID: 30250513

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